EMD-60313

Single-particle
3.15 Å
EMD-60313
3D View Gallery
Deposition: 28/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60313
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EMICSS annotations (xml)

Cryo-EM map of respirasome closed state 1 bound by metformin (SC-MetC1), complex IV focused

EMD-60313

Single-particle
3.15 Å
EMD-60313
3D View Gallery
Deposition: 28/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: Respirasome close state 1 in presence of metformin

Deposition Authors: Teng F , He ZX , Hu YQ , Xu CY, Guo RY, Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z , Teng F , Yang Y , Guo R, Wu M , Han F , Tian H , Wang J, Hu Y , Jiang Y, Zhang L, Xu C, Yang F , Zhou J , Zhang S , Letts JA , Zhou R , Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985