EMD-60304

Single-particle
3.03 Å
EMD-60304
3D View Gallery
Deposition: 28/05/2024
Map released: 17/12/2025
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60304
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
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EMICSS annotations (xml)

Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1), complex III2 focused

EMD-60304

Single-particle
3.03 Å
EMD-60304
3D View Gallery
Deposition: 28/05/2024
Map released: 17/12/2025
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: Respirasome open state 1 in presence of metformin

Deposition Authors: Teng F , He ZX , Hu YQ , Xu CY, Guo RY, Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z , Teng F , Yang Y , Guo R, Wu M, Han F, Tian H, Wang J, Hu Y, Jiang Y, Zhang L, Xu C, Yang F, Zhou J, Zhang S, Letts JA, Zhou R , Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985