EMD-60239

Single-particle
3.07 Å
EMD-60239
3D View Gallery
Deposition: 22/05/2024
Map released: 19/11/2025
Last modified: 19/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60239
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Cryo-EM map of respirasome open state 3 in presence of metformin (SC-MetO3), complex I distal membrane arm focused

EMD-60239

Single-particle
3.07 Å
EMD-60239
3D View Gallery
Deposition: 22/05/2024
Map released: 19/11/2025
Last modified: 19/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: Respirasome open state 3 in presence of metformin

Deposition Authors: Teng F , Hu YQ , Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z, Teng F , Yang Y, Guo R, Wu M, Han F, Tian H, Wang J, Hu Y, Jiang Y, Zhang L, Xu C, Yang F, Zhou J, Zhang S, Letts JA, Zhou R, Zhou L
(2025) Nat Struct Mol Biol
PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985