EMD-59152

Single-particle
2.77 Å
EMD-59152
3D View Gallery
Deposition: 24/07/2026
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-59152

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-32to summary report (pdf.gz) Map-32to FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor IID432

EMD-59152

Single-particle
2.77 Å
EMD-59152
3D View Gallery
Deposition: 24/07/2026
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Trypanosoma cruzi, Escherichia coli
Sample: Topoisomerase II alpha bound to cleaved dsDNA and inhibitor IID432
Fitted models: 32to

Deposition Authors: Schenk A, Deniston C
IID432, a parasite-selective topoisomerase II inhibitor, achieves rapid single-dose parasite clearance in a murine chronic Chagas model.
Saldivia M, Jumani RS, Thomas B, Baxley GM, Sancheti J, Bullara D, Galarneau JR, Cheung H, Chen YL, DeAsis RS, Patra D, Rene O, Noeske J, Schenk AD, Deniston C, Thakore S, Luu C, Wartchow C, Koester DC, Francisco AF, Blais J, Jiricek J, Hollingsworth SA, Gable JE, Kelly JM, Hochberg N, Knutson CG, Lakshminarayana SB, Sarko C, Manjunatha UH, Osborne CS, Diagana TT, Rao SPS
(2026) PNAS , 123 , e2620085123 - e2620085123
PUBMED: 42715074
DOI: doi:10.1073/pnas.2620085123
ISSN: 1091-6490
ASTM: PNASA6
Grant Support: