EMD-58555
CryoEM structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes complexed with an anti-PA-domain monoclonal antibody
EMD-58555
Single-particle3.07 Å
Deposition: 12/06/2026Map released: 01/07/2026
Last modified: 22/07/2026
Sample Organism:
Streptococcus pyogenes,
Mus musculus
Sample: SpyCEP complexed with 3F2G10
Fitted models: 31mr
Deposition Authors: Lau RJ
,
Barritt JD,
Wu GHY,
Huemer CB ,
Matthews S
Sample: SpyCEP complexed with 3F2G10
Fitted models: 31mr
Deposition Authors: Lau RJ
,
Barritt JD,
Wu GHY,
Huemer CB ,
Matthews S
SpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting.
Lau RJ ,
Giblin SP ,
Sugar A,
Di Maio A ,
Tassini G ,
Huse K ,
Chorev D ,
Chen Y,
Wu GH ,
Huemer CB ,
Kim SY,
Matthews J,
Muloud B,
Chen L ,
McKenna S,
Xu Y,
Massai L,
Muzzi C ,
Ferhati X ,
Necchi F ,
Gomes Moriel D,
Feizi T ,
Liu Y ,
Pease JE ,
Sriskandan S ,
Matthews S
(2026) PNAS , 123 , e2520164123 - e2520164123
,
Giblin SP ,
Sugar A,
Di Maio A ,
Tassini G ,
Huse K ,
Chorev D ,
Chen Y,
Wu GH ,
Huemer CB ,
Kim SY,
Matthews J,
Muloud B,
Chen L ,
McKenna S,
Xu Y,
Massai L,
Muzzi C ,
Ferhati X ,
Necchi F ,
Gomes Moriel D,
Feizi T ,
Liu Y ,
Pease JE ,
Sriskandan S ,
Matthews S
(2026) PNAS , 123 , e2520164123 - e2520164123
Grant Support:
- Medical Research Council (MRC, United Kingdom): UKRI682 (United Kingdom)