Single particle reconstruction
3.8Å resolution

Structure of the capsaicin receptor, TRPV1, in complex with DkTx and RTX determined by single particle electron cryo-microscopy

Map released:
Last modified:
Overview of EMD-5776
Source organism: Rattus norvegicus [10116]
Fitted atomic model: 3j5q
Related EM entry by publication: EMD-5777
Primary publication:
TRPV1 structures in distinct conformations reveal mechanisms of activation
Cao E, Liao M, Cheng Y, Julius D
NATURE 504 113-118 (2013)
PMID: 24305161

Function and Biology Details

Sample name: Rat TRPV1 in complex with DkTx and resiniferatoxin
Protein: TRPV1

Experimental Information Details

Resolution: 3.8Å
Resolution method: Gold standard FSC at 0.143 cut-off
Applied symmetry: C4
Reconstruction software: RELION
Microscope: FEI POLARA 300
Detector: GATAN K2 (4k x 4k)