EMD-57299

Single-particle
3.34 Å
EMD-57299
3D View Gallery
Deposition: 31/03/2026
Map released: 06/05/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-57299

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CUL1 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088

EMD-57299

Single-particle
3.34 Å
EMD-57299
3D View Gallery
Deposition: 31/03/2026
Map released: 06/05/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: SCF FBXO22, NSD2, UNC10088

Deposition Authors: Amann SJ , Robertson KC, Grishkovskaya I , Liu T , James LI , Brown NB, Haselbach D
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.
Robertson KC, Amann SJ , Liu T , Funk AV , Wang X, Grishkovskaya I , Mehmood A, Tabor JR, Norris-Drouin JL, Arrowsmith CH, Collins JL , Miao Y , Emanuele MJ , Haselbach D , James LI , Brown NG
(2026) Nat Commun , 17
PUBMED: 42026065
DOI: doi:10.1038/s41467-026-72235-9
ISSN: 2041-1723