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EMD-56330

Tomography
EMD-56330
Gallery
Deposition: 12/01/2026
Map released: 18/02/2026
Last modified: 18/02/2026
Overview Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-56330
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

In situ cryo-ET tomogram of lysosomal structure in LLOMe-treated (0.5mM, 1h) rat hippocampal neuron.

EMD-56330

Tomography
EMD-56330
Gallery
Deposition: 12/01/2026
Map released: 18/02/2026
Last modified: 18/02/2026
Overview Sample Experiment Validation Additional data Links
Sample Organism: Rattus
Sample: Rat hippocampal neuron

Deposition Authors: Li D , Schwarz A , Wilfling F
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes.
Li D , Zhang W, Medina M, Stuke JFM, Schwarz A , Brill J, Brenner J, Kraus F, Ohlerich S, Lizarrondo J, Pflaum J, Grass JH, Soltow LM, Hammerschmid D, Weber N, Welsch S, Langer JD, Windbergs M, Harper JW, Schuman E, Hummer G, Grotjahn DA, Wilfling F
(2026) bioRxiv
PUBMED: 41648416
DOI: doi:10.64898/2026.01.17.700056
ISSN: 2692-8205
Grant Support:
  • Aligning Science Across Parkinsons (ASAP): ASAP-000282/ASAP-024268 (United States)
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