EMD-56329

Tomography
EMD-56329
Gallery
Deposition: 12/01/2026
Map released: 18/02/2026
Last modified: 18/02/2026
Overview Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-56329

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

In situ cryo-ET tomogram of lysosomes in E64d pre-treated (20uM, 30min) and LLOMe (0.5mM, 60min) treated TMEM192-3xHA HeLa cell.

EMD-56329

Tomography
EMD-56329
Gallery
Deposition: 12/01/2026
Map released: 18/02/2026
Last modified: 18/02/2026
Overview Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: HeLa TMEM192-3xHA cell

Deposition Authors: Li D , Wilfling F
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes.
Li D , Zhang W , Medina M , Stuke JFM , Schwarz A , Brill J, Brenner J , Kraus F , Ohlerich S, Lizarrondo J , Pflaum J , Grass JH , Soltow LM, Hammerschmid D , Weber N, Welsch S , Langer JD, Windbergs M , Harper JW , Schuman E, Hummer G , Grotjahn DA , Wilfling F
(2026) bioRxiv
PUBMED: 41648416
DOI: doi:10.64898/2026.01.17.700056
ISSN: 2692-8205