EMD-55655
Focused map of CUL2-LRRC58-EloC interface region from LRRC58- EloB/C-CDO1 in complex with neddylated CUL2-RBX1-ARIH1-Ub
EMD-55655
Single-particle3.5 Å
Deposition: 11/11/2025Map released: 20/05/2026
Last modified: 20/05/2026
Sample Organism:
Homo sapiens
Sample: LRRC58-EloB/C-CDO1 in complex with neddylated CUL2-RBX1-ARIH1-Ub
Deposition Authors: Stier L
,
Andree GA
,
Schulman BA
Sample: LRRC58-EloB/C-CDO1 in complex with neddylated CUL2-RBX1-ARIH1-Ub
Deposition Authors: Stier L
,
Andree GA
,
Schulman BA
Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1.
Andree GA
,
Stier LJ,
Schmiederer K,
Thielen AS
,
Schmid L,
Maiwald SA,
Gottemukkala KV,
Du J,
von Gronau S,
Strasser C,
Muller J,
Henneberg LT,
Guyot C,
Kleiger G
,
Mann M
,
Murray PJ
,
Schulman BA
(2026) Nat Commun , 17
,
Stier LJ,
Schmiederer K,
Thielen AS
,
Schmid L,
Maiwald SA,
Gottemukkala KV,
Du J,
von Gronau S,
Strasser C,
Muller J,
Henneberg LT,
Guyot C,
Kleiger G
,
Mann M
,
Murray PJ
,
Schulman BA
(2026) Nat Commun , 17
Grant Support:
- European Research Council (ERC): 101098161 (European Union)
- Boehringer Ingelheim Fonds (BIF): (Germany)
