EMD-55235
EloB/EloC/VHL/CV2a/14-3-3zeta/ERa pose 2.1
EMD-55235
Single-particle6.5 Å
Deposition: 30/09/2025Map released: 03/12/2025
Last modified: 02/09/2026
Sample Organism:
Homo sapiens
Sample: Quaternary complex of the VCB (VHL-EloC-EloB) E3 ligase von Hippel-Lindau substrate receptor in complex with small molecule CV2a, 14-3-3zeta and the estrogen receptor alpha
Deposition Authors: Crowe C
,
Nakasone MA ,
Harzing T ,
Verhoef CJA ,
Cossar PJ ,
Ciulli A
Sample: Quaternary complex of the VCB (VHL-EloC-EloB) E3 ligase von Hippel-Lindau substrate receptor in complex with small molecule CV2a, 14-3-3zeta and the estrogen receptor alpha
Deposition Authors: Crowe C
,
Nakasone MA ,
Harzing T ,
Verhoef CJA ,
Cossar PJ ,
Ciulli A
Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC.
Verhoef CJA ,
Crowe C ,
Nakasone MA ,
DeLaCuadra-Baste A,
Harzing T ,
Span NAS,
Sathe G,
Demmers LC,
Iso K,
Ottmann C,
Brunsveld L,
Ciulli A ,
Cossar PJ
(2026) Nat Commun , 17
,
Crowe C ,
Nakasone MA ,
DeLaCuadra-Baste A,
Harzing T ,
Span NAS,
Sathe G,
Demmers LC,
Iso K,
Ottmann C,
Brunsveld L,
Ciulli A ,
Cossar PJ
(2026) Nat Commun , 17
Grant Support:
- European Research Council (ERC): ERC-2012-StG-311460 DrugE3CRLs (European Union)
- European Research Council (ERC): 875510 (European Union)
- Medical Research Council (MRC, United Kingdom): MR/R015791/1 (United Kingdom)