EMD-54920
Cryo-EM structure of the catalytic core of human telomerase at the initiation state of the repeat addition cycle
EMD-54920
Single-particle3.53 Å
Deposition: 28/08/2025Map released: 28/01/2026
Last modified: 04/03/2026
Sample Organism:
Homo sapiens
Sample: Cryo-EM structure of the catalytic core of human telomerase at the initiation state of the repeat addition cycle
Fitted models: 9shy
Deposition Authors: Balch S, Franco-Echevarria E
,
Ghanim GE,
Kretsch RC ,
Das R ,
Nguyen THD ,
Yu H,
Ghanim GE,
Sigurdur TR,
Ding Y,
Das R ,
Nguyen THD
Sample: Cryo-EM structure of the catalytic core of human telomerase at the initiation state of the repeat addition cycle
Fitted models: 9shy
Deposition Authors: Balch S, Franco-Echevarria E
,
Ghanim GE,
Kretsch RC ,
Das R ,
Nguyen THD ,
Yu H,
Ghanim GE,
Sigurdur TR,
Ding Y,
Das R ,
Nguyen THD
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle.
Balch S,
Franco-Echevarria E ,
Ghanim GE,
Kretsch RC ,
Das R ,
Nguyen THD
(2026) Nat Commun , 17 , 1847 - 1847
,
Ghanim GE,
Kretsch RC ,
Das R ,
Nguyen THD
(2026) Nat Commun , 17 , 1847 - 1847
Grant Support:
- UK Research and Innovation (UKRI): MC_UP_1201/19 (United Kingdom)
- European Molecular Biology Organization (EMBO): Young Investigator Program Award (European Union)
- Wellcome Trust: 226015/Z/22/Z (United Kingdom)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): 2R35GM122579 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)