Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-54809

Single-particle
2.91 Å
EMD-54809
3D View Gallery
Deposition: 18/08/2025
Map released: 05/11/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54809
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9seg summary report (pdf.gz) Map and 9seg FULL report (pdf.gz)
EMICSS annotations (xml)

Mouse otoferlin (216-1931) in the lipid-free Ca2+-bound state, "open" conformation (class 1)

EMD-54809

Single-particle
2.91 Å
EMD-54809
3D View Gallery
Deposition: 18/08/2025
Map released: 05/11/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Lipid-free mouse otoferlin (216-1931) in the Ca2+-bound state, "open" conformation (class 1)
Fitted models: 9seg

Deposition Authors: Cretu C, Moser T
Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing.
Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmuller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T
(2025) Sci Adv , 11 , eady8532 - eady8532
PUBMED: 41091875
DOI: doi:10.1126/sciadv.ady8532
ISSN: 2375-2548
Grant Support: