EMD-54632
Ternary cryo-EM structure of human ALG9 with Dol25-PP-GlcNAc2Man8, Dol25-P-Man and Fab
EMD-54632
Single-particle2.95 Å
Deposition: 01/08/2025Map released: 18/03/2026
Last modified: 18/03/2026
Sample Organism:
synthetic construct,
Homo sapiens,
Lama glama
Sample: Ternary complex of human ALG9 with Hs9-8 Fab, anti-kappa light chain nanobody as well as Dol25-P-Man and Dol25-PP-GlcNAc2Man8 substrates
Fitted models: 9s6u
Deposition Authors: Alexander JAN
,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
Sample: Ternary complex of human ALG9 with Hs9-8 Fab, anti-kappa light chain nanobody as well as Dol25-P-Man and Dol25-PP-GlcNAc2Man8 substrates
Fitted models: 9s6u
Deposition Authors: Alexander JAN
,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
Structural basis for oligomannose N-glycan synthesis in the endoplasmic reticulum
Alexander JAN ,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
(2026) Nat Chem Biol
,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
(2026) Nat Chem Biol
Grant Support:
- Swiss National Science Foundation: 310030_196862 (Switzerland)
- Swiss National Science Foundation: 315230_220007 (Switzerland)