EMD-54629
Ternary cryo-EM structure of yeast ALG3 with Dol25-PP-GlcNAc2Man5, Dol25-P-Man, and Fab
EMD-54629
Single-particle3.08 Å
Deposition: 01/08/2025Map released: 18/03/2026
Last modified: 25/03/2026
Sample Organism:
synthetic construct,
Saccharomyces cerevisiae,
Lama glama
Sample: Ternary complex of yeast ALG3 with Sc3-16 Fab, anti-kappa light chain nanobody as well as Dol25-P-Man and Dol25-PP-GlcNAc2Man5 substrates
Fitted models: 9s6r
Deposition Authors: Alexander JAN
,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
Sample: Ternary complex of yeast ALG3 with Sc3-16 Fab, anti-kappa light chain nanobody as well as Dol25-P-Man and Dol25-PP-GlcNAc2Man5 substrates
Fitted models: 9s6r
Deposition Authors: Alexander JAN
,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core.
Alexander JAN ,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
(2026) Nat Chem Biol
,
Chen SY,
Mukherjee S ,
de Capitani M ,
Irobalieva RN ,
Rossi L ,
Agrawal P,
Kowal J,
Meirelles MA ,
Aebi M,
Reymond JL ,
Kossiakoff AA ,
Riniker S ,
Locher KP
(2026) Nat Chem Biol
Grant Support:
- Swiss National Science Foundation: 310030_196862 (Switzerland)
- Swiss National Science Foundation: 315230_220007 (Switzerland)