EMD-54419
Cryo-EM structure of human NHE6 in C2 symmetry
EMD-54419
Single-particle3.4 Å
Deposition: 16/07/2025Map released: 29/07/2026
Last modified: 23/09/2026
Sample Organism:
Homo sapiens
Sample: Homodimeric human NHE6 in C2 symmetry
Fitted models: 9s0s
Deposition Authors: Feilen LP
,
Sach L ,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Brauer CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
Sample: Homodimeric human NHE6 in C2 symmetry
Fitted models: 9s0s
Deposition Authors: Feilen LP
,
Sach L ,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Brauer CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
Integrative structural analysis of human endosomal NHE6 reveals a lipid-associated gate and disordered C-terminus.
Feilen LP ,
Sach LK,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Jeria Cerda CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
(2026) Nat Commun , 17
,
Sach LK,
Tranchant EE ,
Lalic MR,
Havelund JF ,
Jeria Cerda CM,
Ginsthofer M ,
Ostendorf J,
Ma L,
Morrow EM ,
Faergeman NJ ,
Pedersen SF ,
Kragelund BB ,
Autzen HE
(2026) Nat Commun , 17
Grant Support:
- Novo Nordisk Foundation: NNF20OC0060692 (Denmark)
- The Carlsberg Foundation: CF20-0533 (Denmark)
- Independent Research Fund Denmark - Medical Sciences: 1131-00023B (Denmark)
- European Research Council (ERC): 101151923 (European Union)
- Danish Council for Independent Research: 3103-00217B (Denmark)