EMD-54277

Single-particle
3.9 Å
EMD-54277
3D View Gallery
Deposition: 05/07/2025
Map released: 06/05/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54277

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9rux summary report (pdf.gz) Map-9rux FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of DISC1 core

EMD-54277

Single-particle
3.9 Å
EMD-54277
3D View Gallery
Deposition: 05/07/2025
Map released: 06/05/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Tetrameric complex of mDISC1 core
Fitted models: 9rux

Deposition Authors: Zhou JC
The schizophrenia associated protein DISC1 forms a multivalent tetrameric hub via conserved UVR dimers.
Zhou JC, Kratochvil J, Ye F, El Omari K, Kukura P, Zhang M, Seiradake E
(2026) Nat Commun , 17
PUBMED: 41997921
DOI: doi:10.1038/s41467-026-71838-6
ISSN: 2041-1723
Grant Support: