EMD-54151

Single-particle
3.1 Å
EMD-54151
3D View Gallery
Deposition: 24/06/2025
Map released: 18/03/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54151

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9rpb summary report (pdf.gz) Map-9rpb FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

a5b3 GABAAR bound to GABA, and Mb25 in a desensitized state in saposin nanodiscs, topiramate-free

EMD-54151

Single-particle
3.1 Å
EMD-54151
3D View Gallery
Deposition: 24/06/2025
Map released: 18/03/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Escherichia coli
Sample: human a5b3 GABAA receptor bound to GABA and Megabody 25 without Topiramate resolved
Fitted models: 9rpb

Deposition Authors: Cowgill J, Lindahl E , Howard RJ
Structural basis for activation and potentiation in a human alpha 5 beta 3 GABA A receptor.
Cowgill J, Fan C, Steyaert J, Howard RJ , Lindahl E
(2026) Nat Commun , 17
PUBMED: 42297817
DOI: doi:10.1038/s41467-026-74279-3
ISSN: 2041-1723