EMD-54068
SIVtal integrase in complex with RNA stem-loop (focused refinement of the filament repeat unit)
EMD-54068
Single-particle3.3 Å
Deposition: 18/06/2025Map released: 10/12/2025
Last modified: 24/06/2026
Sample Organism:
Simian immunodeficiency virus,
synthetic construct
Sample: Linear Polymer Assembly of SIV Integrase Octamers with RNA Stem-loop (local refinement).
Fitted models: 9rmu
Deposition Authors: Singer MR, Cherepanov P
Sample: Linear Polymer Assembly of SIV Integrase Octamers with RNA Stem-loop (local refinement).
Fitted models: 9rmu
Deposition Authors: Singer MR, Cherepanov P
Integrase anchors viral RNA to the HIV-1 capsid interior.
Singer MR,
Li Z,
Rey JS ,
Hope J ,
Chenavier F ,
Cook NJ ,
Punch E,
Smith J,
Zhou Z ,
Maslen S,
Masino L ,
Nans A ,
Skehel M,
Taylor IA ,
Zanetti G ,
Zhang P ,
Perilla JR ,
Engelman AN ,
Cherepanov P
(2026) Nature , 652 , 1068 - 1075
,
Hope J ,
Chenavier F ,
Cook NJ ,
Punch E,
Smith J,
Zhou Z ,
Maslen S,
Masino L ,
Nans A ,
Skehel M,
Taylor IA ,
Zanetti G ,
Zhang P ,
Perilla JR ,
Engelman AN ,
Cherepanov P
(2026) Nature , 652 , 1068 - 1075
Grant Support:
- Cancer Research UK: CC2058 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): CC2058 (United Kingdom)
- Wellcome Trust: CC2058 (United Kingdom)
- The Francis Crick Institute: CC2058 (United Kingdom)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U54AI170791 (United States)