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EMD-53969

Single-particle
2.5 Å
EMD-53969
3D View Gallery
Deposition: 09/06/2025
Map released: 24/12/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53969
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9rhg summary report (pdf.gz) Map and 9rhg FULL report (pdf.gz)
EMICSS annotations (xml)

FZD7 in complex with negative allosteric modulator C407

EMD-53969

Single-particle
2.5 Å
EMD-53969
3D View Gallery
Deposition: 09/06/2025
Map released: 24/12/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Spodoptera frugiperda, Homo sapiens
Sample: FZD7 in complex with the negative allosteric modulator C407
Fitted models: 9rhg

Deposition Authors: Scharf MM , Graetz L, Kinsolving J , Voss J, Carrasco-Busturia D , Forsberg B, Kolb P , Schulte G
In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.
Scharf MM , Kinsolving J , Gratz L, Voss JH , Carrasco-Busturia D , Forsberg B, Kolb P , Schulte G
(2025) Nat Commun , 16 , 11138 - 11138
PUBMED: 41392205
DOI: doi:10.1038/s41467-025-67147-z
ISSN: 2041-1723