EMD-53847

Single-particle
3.25 Å
EMD-53847
3D View Gallery
Deposition: 18/05/2025
Map released: 04/03/2026
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53847
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9r90 summary report (pdf.gz) Map and 9r90 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human ATP citrate lyase in complex with inhibitor EVT0185-CoA

EMD-53847

Single-particle
3.25 Å
EMD-53847
3D View Gallery
Deposition: 18/05/2025
Map released: 04/03/2026
Last modified: 04/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human ATP citrate lyase (homotetramer)
Fitted models: 9r90

Deposition Authors: Verstraete K , Verschueren K, Savvides SN , Steinberg GR
ACLY inhibition promotes tumour immunity and suppresses liver cancer.
Gautam J, Wu J , Lally JSV, McNicol JD , Fayyazi R, Ahmadi E , Oniciu DC, Heaton S, Newton RS, Rehal S, Bhattacharya D, Di Pastena F, Nguyen B , Valvano CM , Townsend LK , Banskota S , Batchuluun B, Jabile MJT, Payne A, Lu J , Desjardins EM, Kubota N, Tsakiridis EE, Mistry B, Aganostopoulos A, Houde V, Dansercoer A, Verschueren KHG, Savvides SN , Hammill JA, Bezverbnaya K, Muti P, Tsakiridis T , Dai W, Jiang L , Hoshida Y , Larche M , Bramson JL , Friedman SL , Verstraete K , Wang D , Steinberg GR
(2025) Nature , 645 , 507 - 517
PUBMED: 40739358
DOI: doi:10.1038/s41586-025-09297-0
ISSN: 1476-4687
ASTM: NATUAS