EMD-53567

Composite map
Single-particle
2.92 Å
EMD-53567
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Deposition: 07/05/2025
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53567
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9r4i summary report (pdf.gz) Map and 9r4i FULL report (pdf.gz)
EMICSS annotations (xml)

An auto inhibitory loop in the MiDAC histone deacetylase complex

EMD-53567

Composite map
Single-particle
2.92 Å
EMD-53567
3D View Gallery
Deposition: 07/05/2025
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Dimeric complex of HDAC1:MIDEAS:DNTTIP1
Fitted models: 9r4i

Deposition Authors: Fairall L, Schwabe JWR
A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome.
Fairall L, Sirvydis K, Turnbull RE, Knottnerus SJ, Gonchar O, Muskett FW, Jukes-Jones R, van Brussel L, van de Geer E, van Gassen K, Badenhorst P, Johnson D, Terhal PA, van Hasselt PM, van Jaarsveld RH, Schwabe JW
(2025) Nat Commun , 16 , 10472 - 10472
PUBMED: 41290615
DOI: doi:10.1038/s41467-025-65472-x
ISSN: 2041-1723
Grant Support: