EMD-53567

Single-particle
2.92 Å
EMD-53567
3D View Gallery
Deposition: 07/05/2025
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53567

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9r4i summary report (pdf.gz) Map-9r4i FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

An auto inhibitory loop in the MiDAC histone deacetylase complex

EMD-53567

Single-particle
2.92 Å
EMD-53567
3D View Gallery
Deposition: 07/05/2025
Map released: 25/02/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Dimeric complex of HDAC1:MIDEAS:DNTTIP1
Fitted models: 9r4i

Deposition Authors: Fairall L , Schwabe JWR
A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome.
Fairall L , Sirvydis K , Turnbull RE , Knottnerus SJ, Gonchar O, Muskett FW , Jukes-Jones R, van Brussel L, van de Geer E, van Gassen K, Badenhorst P , Johnson D, Terhal PA, van Hasselt PM, van Jaarsveld RH , Schwabe JW
(2025) Nat Commun , 16 , 10472 - 10472
PUBMED: 41290615
DOI: doi:10.1038/s41467-025-65472-x
ISSN: 2041-1723
Grant Support: