EMD-53356
Human alpha7 nicotinic receptor in complex with the E6 nanobody
EMD-53356
Single-particle2.16 Å
Deposition: 09/04/2025Map released: 18/02/2026
Last modified: 18/02/2026
Sample Organism:
Homo sapiens,
Vicugna pacos
Sample: Human nicotinic acetylcholine receptor alpha7 in complex with Nanobody E6
Fitted models: 9qto
Deposition Authors: Barilone N
,
Vangelatou M ,
Marouf FZ ,
Dejean de la Batie G,
Ayme G ,
Lafaye P ,
Corringer P-J,
Prevost MS
Sample: Human nicotinic acetylcholine receptor alpha7 in complex with Nanobody E6
Fitted models: 9qto
Deposition Authors: Barilone N
,
Vangelatou M ,
Marouf FZ ,
Dejean de la Batie G,
Ayme G ,
Lafaye P ,
Corringer P-J,
Prevost MS
Discovery and mechanism of negative allosteric modulation of the alpha 7 nicotinic acetylcholine receptor by nanobodies.
Barilone N ,
Vangelatou M ,
Marouf FZ ,
Dejean de la Batie G,
Li Q,
Lafaye P ,
Ayme G ,
Corringer PJ,
Prevost MS
(2026) PNAS , 123 , e2514734123 - e2514734123
,
Vangelatou M ,
Marouf FZ ,
Dejean de la Batie G,
Li Q,
Lafaye P ,
Ayme G ,
Corringer PJ,
Prevost MS
(2026) PNAS , 123 , e2514734123 - e2514734123
Grant Support:
- European Research Council (ERC): 788974 (European Union)
- Agence Nationale de la Recherche (ANR): ANR-23-CE11-0009-01 (France)