EMD-53340
Cryo-EM structure of the MMM ubiquitin ligase complex with nanobody 992 (Composite map)
EMD-53340
Single-particle3.5 Å
Deposition: 04/04/2025Map released: 27/05/2026
Last modified: 17/06/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: Human MEGF8-MOSMO-MGRN1 (MMM) ternary complex bound to nanobody 992
Fitted models: 9qsh
Deposition Authors: Williams C, Carrique L
,
Pardon E ,
Nocka LM,
Hedger G ,
Pusapati GV ,
Parashara P,
Sarkar P,
Latorraca NR,
Lartey D,
Gao L,
Milenkovic L,
Steyaert J ,
Bazan F,
Rouse SL,
Marqusee S,
Kong JH ,
Rohatgi R,
Siebold C
Sample: Human MEGF8-MOSMO-MGRN1 (MMM) ternary complex bound to nanobody 992
Fitted models: 9qsh
Deposition Authors: Williams C, Carrique L
,
Pardon E ,
Nocka LM,
Hedger G ,
Pusapati GV ,
Parashara P,
Sarkar P,
Latorraca NR,
Lartey D,
Gao L,
Milenkovic L,
Steyaert J ,
Bazan F,
Rouse SL,
Marqusee S,
Kong JH ,
Rohatgi R,
Siebold C
Design principles of a membrane-spanning ubiquitin ligase.
Williams C,
Nocka LM,
Hedger G ,
Parashara P,
Pardon E ,
Latorraca NR,
Pusapati GV ,
Sarkar P,
Lartey D,
Gao L,
Milenkovic L,
Chalk R ,
Steyaert J ,
Marqusee S,
Carrique L ,
Bazan JF,
Rouse SL,
Kong JH ,
Siebold C,
Rohatgi R
(2026) Mol Cell , 86 , 2207
,
Parashara P,
Pardon E ,
Latorraca NR,
Pusapati GV ,
Sarkar P,
Lartey D,
Gao L,
Milenkovic L,
Chalk R ,
Steyaert J ,
Marqusee S,
Carrique L ,
Bazan JF,
Rouse SL,
Kong JH ,
Siebold C,
Rohatgi R
(2026) Mol Cell , 86 , 2207
Grant Support:
- Cancer Research UK: DRCRPG-May23/100002 (United Kingdom)
- Cancer Research UK: C20724/A26752 (United Kingdom)
- Wellcome Trust: 218482/Z/19/Z (United Kingdom)
- Wellcome Trust: 060208/Z/00/Z (United Kingdom)
- Wellcome Trust: 093305/Z/10/Z (United Kingdom)