EMD-53328
Focused refinement of the MGRN1 ubiquitin ligase in complex with helix-stabilized MEGF8, MOSMO and nanobody 270
EMD-53328
Single-particle4.41 Å
Deposition: 04/04/2025Map released: 27/05/2026
Last modified: 17/06/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: Helix-stabilized human MEGF8-MOSMO-MGRN1 (MMM) ternary complex bound to nanobody 270
Deposition Authors: Williams C
,
Carrique L ,
Pardon E ,
Nocka LM ,
Hedger G ,
Pusapati GV ,
Parashara P ,
Latorraca NR ,
Sarkar P ,
Lartey D ,
Gao L ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Bazan F ,
Rouse SL ,
Marqusee S ,
Kong JH ,
Rohatgi R ,
Siebold C
Sample: Helix-stabilized human MEGF8-MOSMO-MGRN1 (MMM) ternary complex bound to nanobody 270
Deposition Authors: Williams C
,
Carrique L ,
Pardon E ,
Nocka LM ,
Hedger G ,
Pusapati GV ,
Parashara P ,
Latorraca NR ,
Sarkar P ,
Lartey D ,
Gao L ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Bazan F ,
Rouse SL ,
Marqusee S ,
Kong JH ,
Rohatgi R ,
Siebold C
Design principles of a membrane-spanning ubiquitin ligase.
Williams C ,
Nocka LM ,
Hedger G ,
Parashara P ,
Pardon E ,
Latorraca NR ,
Pusapati GV ,
Sarkar P ,
Lartey D ,
Gao L ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Marqusee S ,
Carrique L ,
Bazan JF,
Rouse SL ,
Kong JH ,
Siebold C ,
Rohatgi R
(2026) Mol Cell , 86 , 2207 - 2222.e16
,
Nocka LM ,
Hedger G ,
Parashara P ,
Pardon E ,
Latorraca NR ,
Pusapati GV ,
Sarkar P ,
Lartey D ,
Gao L ,
Milenkovic L ,
Chalk R ,
Steyaert J ,
Marqusee S ,
Carrique L ,
Bazan JF,
Rouse SL ,
Kong JH ,
Siebold C ,
Rohatgi R
(2026) Mol Cell , 86 , 2207 - 2222.e16
Grant Support:
- Cancer Research UK: DRCRPG-May23/100002 (United Kingdom)
- Cancer Research UK: C20724/A26752 (United Kingdom)
- Wellcome Trust: 218482/Z/19/Z (United Kingdom)
- Wellcome Trust: 060208/Z/00/Z (United Kingdom)
- Wellcome Trust: 093305/Z/10/Z (United Kingdom)