EMD-53004

Single-particle
2.83 Å
EMD-53004
3D View Gallery
Deposition: 04/03/2025
Map released: 13/05/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53004

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9qc6 summary report (pdf.gz) Map-9qc6 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)

EMD-53004

Single-particle
2.83 Å
EMD-53004
3D View Gallery
Deposition: 04/03/2025
Map released: 13/05/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)
Fitted models: 9qc6

Deposition Authors: Shilliday F, Maia de Oliveira T, Gancedo-Rodrigo M
A molecular stabiliser of an inhibitory eIF2B-eIF2( alpha P) complex activates the Integrated Stress Response.
Shilliday F, Gancedo-Rodrigo M, George G, Aibara S, Adhikari S, Ashraf SN, Barrey EJ, Centrella PA, Crowther D, Dickson P, Gikunju D, Guie MA, Guilinger JP, Gunnarsson A, Harding HP, Hupp CD, Jetson R, Keefe AD, Kim JM, Lewis RJ, Maia de Oliveira T, Le-Marshall J, Narayanan U, Nugai KA, Petrovic D, Rivers E, Ron D, Stringfellow D, Syson K, Ward L, Yeoman JTS, Yu Y, Zhang Y, Zyryanova A, Baker DJ, Breccia P, Linley JE
(2026) Nat Commun , 17
PUBMED: 42091608
DOI: doi:10.1038/s41467-026-72688-y
ISSN: 2041-1723
Grant Support: