EMD-52968

Single-particle
3.9 Å
EMD-52968
3D View Gallery
Deposition: 27/02/2025
Map released: 03/09/2025
Last modified: 29/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52968
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9q9z summary report (pdf.gz) Map and 9q9z FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the helicase core of ZNFX1

EMD-52968

Single-particle
3.9 Å
EMD-52968
3D View Gallery
Deposition: 27/02/2025
Map released: 03/09/2025
Last modified: 29/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: ZNFX1
Fitted models: 9q9z

Deposition Authors: Grabarczyk DB , Reznikow V, Kurzbauer R, Clausen T
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles.
Grabarczyk DB , Aird EJ, Reznikow V, Kirchgatterer PC, Ehrmann JF, Kurzbauer R, Bell LE, Kellner MJ, Aggarwal R, Schleiffer A, Faas V, Deszcz L, Meinhart A, Versteeg GA, Penninger JM, Stelzl LS, Gaidt MM, Tessmer I, Corn JE, Clausen T
(2025) Cell , 188 , 5995
PUBMED: 40876457
DOI: doi:10.1016/j.cell.2025.08.006
ISSN: 1097-4172