EMD-52888
In-situ structure of HIV-1 CA hexamer before the nuclear import
EMD-52888
Subtomogram averaging11.05 Å
Deposition: 22/02/2025Map released: 19/03/2025
Last modified: 17/09/2025
Sample Organism:
HIV-1
Sample: HIV-1 CA protein hexamer
Deposition Authors: Hou Z
,
Zhang P ,
Shen Y ,
Fronik S ,
Shen J,
Shi J,
Xu J,
Chen L ,
Hardenbrook N,
Thompson C,
Neumann S,
Engelman A,
Aiken C
Sample: HIV-1 CA protein hexamer
Deposition Authors: Hou Z
,
Zhang P ,
Shen Y ,
Fronik S ,
Shen J,
Shi J,
Xu J,
Chen L ,
Hardenbrook N,
Thompson C,
Neumann S,
Engelman A,
Aiken C
HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability.
Hou Z ,
Shen Y ,
Fronik S ,
Shen J,
Shi J,
Xu J,
Chen L ,
Hardenbrook N,
Engelman AN ,
Aiken C,
Zhang P
(2025) Nat Microbiol , 10 , 1868 - 1885
,
Shen Y ,
Fronik S ,
Shen J,
Shi J,
Xu J,
Chen L ,
Hardenbrook N,
Engelman AN ,
Aiken C,
Zhang P
(2025) Nat Microbiol , 10 , 1868 - 1885
Grant Support:
- Wellcome Trust: 203141/Z/16/Z (United Kingdom)