EMD-52815

Single-particle
2.54 Å
EMD-52815
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Deposition: 14/02/2025
Map released: 04/06/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52815
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ibx summary report (pdf.gz) Map and 9ibx FULL report (pdf.gz)
EMICSS annotations (xml)

Chimeric mitochondrial DNA polymerase gamma ternary complex (mAhB) in replication conformer

EMD-52815

Single-particle
2.54 Å
EMD-52815
3D View Gallery
Deposition: 14/02/2025
Map released: 04/06/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens, synthetic construct
Sample: Chimeric mitochondrial DNA polymerase gamma ternary complex (mAhB) in replication conformer
Fitted models: 9ibx

Deposition Authors: Valenzuela S , Falkenberg M
Modelling POLG mutations in mice unravels a critical role of POL gamma Beta in regulating phenotypic severity.
Corra S, Zuppardo A , Valenzuela S , Jenninger L, Cerutti R, Sillamaa S , Hoberg E, Johansson KAS , Rovsnik U, Volta S, Silva-Pinheiro P , Davis H, Trifunovic A , Minczuk M , Gustafsson CM , Suomalainen A , Zeviani M, Macao B , Zhu X , Falkenberg M , Viscomi C
(2025) Nat Commun , 16 , 4782 - 4782
PUBMED: 40404629
DOI: doi:10.1038/s41467-025-60059-y
ISSN: 2041-1723
Grant Support: