EMD-52659

Single-particle
3.98 Å
EMD-52659
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Deposition: 31/01/2025
Map released: 26/11/2025
Last modified: 26/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52659
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A subunit of alpha-1 antitrypsin polymers isolated from ZZ explant liver tissue and decorated with conformationally nonselective Fab 9C5

EMD-52659

Single-particle
3.98 Å
EMD-52659
3D View Gallery
Deposition: 31/01/2025
Map released: 26/11/2025
Last modified: 26/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Complex of the 9C5 Fab fragment and a subunit of polymers of the severe deficiency Z alpha-1 antitrypsin variant

Deposition Authors: Aldobiyan IF , Irving JA , Orlova EV , Lomas DA
The mechanism of pathogenic alpha 1 -antitrypsin aggregation in the human liver.
Aldobiyan I , Elliston ELK, Heyer-Chauhan N , Arold ST , Zhao L , Huntington B , Lowen SM , Orlova EV , Irving JA , Lomas DA
(2025) PNAS , 122 , e2507535122 - e2507535122
PUBMED: 41231946
DOI: doi:10.1073/pnas.2507535122
ISSN: 1091-6490
ASTM: PNASA6