EMD-52412

Single-particle
3.2 Å
EMD-52412
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Deposition: 23/12/2024
Map released: 22/10/2025
Last modified: 12/11/2025
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Overview 3D View Sample Experiment Validation Additional data Links

EMD-52412
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CryoEM structure of human peptidylarginine deiminase type 4 (PAD4) in complex with heparin oligomer (20 subunits) in 0.1 mM calcium

EMD-52412

Single-particle
3.2 Å
EMD-52412
3D View Gallery
Deposition: 23/12/2024
Map released: 22/10/2025
Last modified: 12/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human peptidylarginine deiminase type 4 (PAD4) in complex with heparin oligomer (20 subunits) in 0.1 mM calcium

Deposition Authors: Bereta GP , Bielecka E , Biela AP , Wilk P , Wator-Wilk E , Grudnik P , Kantyka T
Glycosaminoglycans activate peptidylarginine deiminase 4 by enhancing calcium affinity.
Bereta GP , Bielecka E , Marzec K, Pijanowski L , Biela AP , Wilk P , Kaminska M , Nowak J, Wator-Wilk E , Grudnik P , Kowalczyk D , Koziel J , Mydel P, Poreba M , Kantyka T
(2025) PNAS , 122 , e2508369122 - e2508369122
PUBMED: 41166417
DOI: doi:10.1073/pnas.2508369122
ISSN: 1091-6490
ASTM: PNASA6