EMD-52409

Single-particle
2.49 Å
EMD-52409
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Deposition: 22/12/2024
Map released: 25/02/2026
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52409
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9hue summary report (pdf.gz) Map and 9hue FULL report (pdf.gz)
EMICSS annotations (xml)

Outward-open structure of human glycine transporter 2 bound to allosteric inhibitor ORG25543

EMD-52409

Single-particle
2.49 Å
EMD-52409
3D View Gallery
Deposition: 22/12/2024
Map released: 25/02/2026
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human glycine transporter GlyT2 bound to allosteric inhibitor ORG25543
Fitted models: 9hue

Deposition Authors: Cantwell Chater RP, Peiser-Oliver J, Pati TK, Quinn AS, Lotsaris I, Frangos ZJ, Anderson KE, Tischer AE, Williams-Noonan BJ, Aubrey KR, O Mara ML, Michaelides M, Mohammadi SA, Cioffi CL, Vandenberg RJ, Shahsavar A
A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects.
Cantwell Chater RP, Peiser-Oliver J, Pati TK, Quinn AS, Lotsaris I, Frangos ZJ, Anderson KE, Tischer AE, Williams-Noonan BJ, Aubrey KR, O'Mara ML, Michaelides M, Mohammadi SA, Cioffi CL, Vandenberg RJ, Shahsavar A
(2025) bioRxiv
PUBMED: 41332641
DOI: doi:10.1101/2025.04.21.649698
ISSN: 2692-8205