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EMD-52245
TRPML1 in complex with compound 4a
EMD-52245
Single-particle2.2 Å
Deposition: 04/12/2024Map released: 04/06/2025
Last modified: 17/12/2025
Sample Organism:
Homo sapiens
Sample: Mucolipin-1
Fitted models: 9hl6
Deposition Authors: Reeks J
,
Mahajan P ,
Clark M,
Cowan SR,
Di Daniel E ,
Earl CP ,
Fisher S,
Holvey RS ,
Jackson SM ,
Lloyd-Evans E ,
Morgillo CM ,
Mortenson PN ,
O'Reilly M ,
Richardson CJ,
Schopf P,
Tams DM ,
Waller-Evans H ,
Ward SE ,
Whibley S,
Williams PA ,
Johnson CN
Sample: Mucolipin-1
Fitted models: 9hl6
Deposition Authors: Reeks J
,
Mahajan P ,
Clark M,
Cowan SR,
Di Daniel E ,
Earl CP ,
Fisher S,
Holvey RS ,
Jackson SM ,
Lloyd-Evans E ,
Morgillo CM ,
Mortenson PN ,
O'Reilly M ,
Richardson CJ,
Schopf P,
Tams DM ,
Waller-Evans H ,
Ward SE ,
Whibley S,
Williams PA ,
Johnson CN
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1.
Reeks J ,
Mahajan P ,
Clark M,
Cowan SR,
Di Daniel E ,
Earl CP ,
Fisher S,
Holvey RS ,
Jackson SM ,
Lloyd-Evans E ,
Morgillo CM ,
Mortenson PN ,
O'Reilly M ,
Richardson CJ,
Schopf P,
Tams DM ,
Waller-Evans H ,
Ward SE ,
Whibley S,
Williams PA ,
Johnson CN
(2025) Structure , 33 , 1374 - 1385.e7
,
Mahajan P ,
Clark M,
Cowan SR,
Di Daniel E ,
Earl CP ,
Fisher S,
Holvey RS ,
Jackson SM ,
Lloyd-Evans E ,
Morgillo CM ,
Mortenson PN ,
O'Reilly M ,
Richardson CJ,
Schopf P,
Tams DM ,
Waller-Evans H ,
Ward SE ,
Whibley S,
Williams PA ,
Johnson CN
(2025) Structure , 33 , 1374 - 1385.e7
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