EMD-52205

Single-particle
2.6 Å
EMD-52205
3D View Gallery
Deposition: 27/11/2024
Map released: 20/08/2025
Last modified: 20/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52205
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9hix summary report (pdf.gz) Map and 9hix FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of CAK (CDK7 D97N mutant) in complex with THZ1

EMD-52205

Single-particle
2.6 Å
EMD-52205
3D View Gallery
Deposition: 27/11/2024
Map released: 20/08/2025
Last modified: 20/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: CDK-activating kinase (CAK)
Fitted models: 9hix

Deposition Authors: Cushing VI , Greber BJ , Ali S , Lai C-F , Bevan CL , Coombes RC , Buluwela L

Mutation of CDK7 at a conserved residue identifies a common mechanism of acquired resistance to CDK inhibitors in cancer
Lai C-F , Cushing VI , Bevan CL , Coombes RC , Greber BJ , Buluwela L, Ali S
To Be Published