EMD-51986

Single-particle
2.5 Å
EMD-51986
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Deposition: 04/11/2024
Map released: 10/09/2025
Last modified: 10/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51986
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EMICSS annotations (xml)

Local refinement TVP-V2R (Cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with tolvaptan)

EMD-51986

Single-particle
2.5 Å
EMD-51986
3D View Gallery
Deposition: 04/11/2024
Map released: 10/09/2025
Last modified: 10/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Inactive V2R-bril bound to tolvaptan stabillized with anti-BRIL Fab and anti-BRIL Fab Nanobody

Deposition Authors: Bous J , Fouillen A , Couvineau P , Orcel H , Mary C, Mendre C , Schulte G , Granier S , Gilles N , Mouillac B
Inactive structures of the vasopressin V2 receptor reveal distinct binding modes for Tolvaptan and Mambaquaretin toxin.
Fouillen A , Bous J , Couvineau P , Orcel H , Mary C, Lafleur L, Pierre T, Mendre C , Gilles N , Schulte G , Granier S , Mouillac B
(2025) Nat Commun , 16 , 3899 - 3899
PUBMED: 40274867
DOI: doi:10.1038/s41467-025-59114-5
ISSN: 2041-1723