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EMD-51729

Single-particle
3.15 Å
EMD-51729
3D View Gallery
Deposition: 04/10/2024
Map released: 30/07/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51729
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9gzo summary report (pdf.gz) Map and 9gzo FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the human mitochondrial RNA polymerase transcription initiation complex (POLRMT/TFB2M/DNA/RNA) without TFAM; and with a slipped 3-mer RNA, pppGpGpA (slipped IC3-TFAM)

EMD-51729

Single-particle
3.15 Å
EMD-51729
3D View Gallery
Deposition: 04/10/2024
Map released: 30/07/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Cryo-EM structure of the human mitochondrial RNA polymerase transcription initiation complex (POLRMT/TFB2M/DNA/RNA) without TFAM; and with a slipped 3-mer RNA, pppGpGpA (slipped IC3-TFAM)
Fitted models: 9gzo

Deposition Authors: Goovaerts Q , Shen J, Ajjugal Y , De Wijngaert B, Patel SS , Das K
Human mitochondrial RNA polymerase structures reveal transcription start site and slippage mechanism.
Shen J, Goovaerts Q , Ajjugal Y , De Wijngaert B, Das K , Patel SS
(2025) Mol Cell , 85 , 3137 - 3150.e7
PUBMED: 40712586
DOI: doi:10.1016/j.molcel.2025.07.002
ISSN: 1097-2765
ASTM: MOCEFL