EMD-51524

Single-particle
3.9 Å
EMD-51524
3D View Gallery
Deposition: 13/09/2024
Map released: 04/12/2024
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51524
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

Maps from particle subsets of methylamine treated human complement C3 showing three distinct ANA positions

EMD-51524

Single-particle
3.9 Å
EMD-51524
3D View Gallery
Deposition: 13/09/2024
Map released: 04/12/2024
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: methylamine treated complement C3 in complex with a nanobody enabling dimer formation

Deposition Authors: Joergensen MH , Andersen GR
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring.
Gadeberg TAF, Jorgensen MH , Olesen HG, Lorentzen J , Harwood SL, Almeida AV, Fruergaard MU, Jensen RK , Kanis P , Pedersen H, Tranchant E , Petersen SV, Thogersen IB, Kragelund BB , Lyons JA , Enghild JJ , Andersen GR
(2025) Nat Struct Mol Biol , 32 , 884 - 895
PUBMED: 39849196
DOI: doi:10.1038/s41594-024-01467-4
ISSN: 1545-9985