EMD-51328

Single-particle
2.67 Å
EMD-51328
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Deposition: 13/08/2024
Map released: 16/04/2025
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51328
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ggd summary report (pdf.gz) Map and 9ggd FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of the A467T mutant of human mitochondrial DNA polymerase gamma in complex with PZL-A

EMD-51328

Single-particle
2.67 Å
EMD-51328
3D View Gallery
Deposition: 13/08/2024
Map released: 16/04/2025
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Structure of the A467T mutant of human mitochondrial DNA polymerase gamma in complex with PZL-A
Fitted models: 9ggd

Deposition Authors: Valenzuela S , Falkenberg M
Small molecules restore mutant mitochondrial DNA polymerase activity.
Valenzuela S , Zhu X, Macao B, Stamgren M, Geukens C, Charifson PS, Kern G, Hoberg E, Jenninger L, Gruszczyk AV , Lee S, Johansson KAS , Miralles Fuste J , Shi Y, Kerns SJ, Arabanian L, Martinez Botella G, Ekstrom S, Green J , Griffin AM, Pardo-Hernandez C, Keating TA , Kuppers-Munther B, Larsson NG , Phan C, Posse V , Jones JE, Xie X, Giroux S , Gustafsson CM , Falkenberg M
(2025) Nature , 642 , 501 - 507
PUBMED: 40205042
DOI: doi:10.1038/s41586-025-08856-9
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: