EMD-51327

Single-particle
2.39 Å
EMD-51327
3D View Gallery
Deposition: 13/08/2024
Map released: 16/04/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-51327
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ggc summary report (pdf.gz) Map and 9ggc FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of the G848S mutant of human mitochondrial DNA polymerase gamma

EMD-51327

Single-particle
2.39 Å
EMD-51327
3D View Gallery
Deposition: 13/08/2024
Map released: 16/04/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Structure of the G848S mutant of human mitochondrial DNA polymerase gamma
Fitted models: 9ggc

Deposition Authors: Valenzuela S , Falkenberg M
Small molecules restore mutant mitochondrial DNA polymerase activity.
Valenzuela S , Zhu X, Macao B, Stamgren M, Geukens C, Charifson PS, Kern G, Hoberg E, Jenninger L, Gruszczyk AV , Lee S, Johansson KAS , Miralles Fuste J , Shi Y, Kerns SJ, Arabanian L, Martinez Botella G, Ekstrom S, Green J , Griffin AM, Pardo-Hernandez C, Keating TA , Kuppers-Munther B, Larsson NG , Phan C, Posse V , Jones JE, Xie X, Giroux S , Gustafsson CM , Falkenberg M
(2025) Nature , 642 , 501 - 507
PUBMED: 40205042
DOI: doi:10.1038/s41586-025-08856-9
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: