EMD-50317

Single-particle
2.7 Å
EMD-50317
3D View Gallery
Deposition: 15/05/2024
Map released: 04/09/2024
Last modified: 25/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-50317

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9fcj summary report (pdf.gz) Map-9fcj FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement)

EMD-50317

Single-particle
2.7 Å
EMD-50317
3D View Gallery
Deposition: 15/05/2024
Map released: 04/09/2024
Last modified: 25/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: USP1 BOUND TO ML323 AND UBIQUITIN CONJUGATED TO FANCD2
Fitted models: 9fcj

Deposition Authors: Rennie ML , Gundogdu M, Walden H
Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
Rennie ML , Gundogdu M, Arkinson C, Liness S, Frame S, Walden H
(2024) J Med Chem , 67 , 15557 - 15568
PUBMED: 39190802
DOI: doi:10.1021/acs.jmedchem.4c01184
ISSN: 0022-2623
ASTM: JMCMAR