EMD-50316

Single-particle
3.2 Å
EMD-50316
3D View Gallery
Deposition: 15/05/2024
Map released: 04/09/2024
Last modified: 25/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-50316

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9fci summary report (pdf.gz) Map-9fci FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement)

EMD-50316

Single-particle
3.2 Å
EMD-50316
3D View Gallery
Deposition: 15/05/2024
Map released: 04/09/2024
Last modified: 25/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: USP1 BOUND TO KSQ-4279 AND UBIQUITIN CONJUGATED TO FANCD2
Fitted models: 9fci

Deposition Authors: Rennie ML , Gundogdu M, Walden H
Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
Rennie ML , Gundogdu M, Arkinson C, Liness S, Frame S, Walden H
(2024) J Med Chem , 67 , 15557 - 15568
PUBMED: 39190802
DOI: doi:10.1021/acs.jmedchem.4c01184
ISSN: 0022-2623
ASTM: JMCMAR