EMD-50137

Helical reconstruction
4.13 Å
EMD-50137
3D View Gallery
Deposition: 20/04/2024
Map released: 26/02/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-50137

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9f20 summary report (pdf.gz) Map-9f20 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the I923V MDA5-dsRNA filament with ADP-AlF4 bound and 88-degree helical twist

EMD-50137

Helical reconstruction
4.13 Å
EMD-50137
3D View Gallery
Deposition: 20/04/2024
Map released: 26/02/2025
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Mouse MDA5 I923V in complex with double stranded RNA
Fitted models: 9f20

Deposition Authors: Singh R , Herrero del Valle A, Modis Y
Molecular basis of autoimmune disease protection by MDA5 variants.
Singh R , Joiner JD , Herrero Del Valle A, Zwaagstra M, Jobe I, Ferguson BJ, van Kuppeveld FJM, Modis Y
(2025) Cell Rep , 44 , 115754 - 115754
PUBMED: 40450684
DOI: doi:10.1016/j.celrep.2025.115754
ISSN: 2211-1247