EMD-49942
Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 24
EMD-49942
Single-particle3.9 Å
Deposition: 28/03/2025Map released: 04/02/2026
Last modified: 04/02/2026
Sample Organism:
Homo sapiens
Sample: CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 24
Fitted models: 9nyr
Deposition Authors: Collier P, Zheng X
,
Ford M,
Weiss M,
Aversa R,
Chen D,
Li K,
Growney JD ,
Yang A,
Sathappa M,
Breitkopf SB,
Enerson B,
Sawant R,
Su L ,
Howarth L,
Liang T,
Paul A ,
Sharma K ,
Williams J,
Kwiatkowski NP
Sample: CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 24
Fitted models: 9nyr
Deposition Authors: Collier P, Zheng X
,
Ford M,
Weiss M,
Aversa R,
Chen D,
Li K,
Growney JD ,
Yang A,
Sathappa M,
Breitkopf SB,
Enerson B,
Sawant R,
Su L ,
Howarth L,
Liang T,
Paul A ,
Sharma K ,
Williams J,
Kwiatkowski NP
Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2.
Collier PN ,
Zheng X ,
Ford M,
Weiss M,
Chen D,
Li K,
Growney JD ,
Yang A,
Sathappa M,
Breitkopf SB,
Enerson B,
Liang T,
Paul A ,
Sawant R,
Su L ,
Aversa RJ ,
Howarth C,
Sharma K ,
Williams J,
Kwiatkowski NP
(2025) J Med Chem , 68 , 18407 - 18422
,
Zheng X ,
Ford M,
Weiss M,
Chen D,
Li K,
Growney JD ,
Yang A,
Sathappa M,
Breitkopf SB,
Enerson B,
Liang T,
Paul A ,
Sawant R,
Su L ,
Aversa RJ ,
Howarth C,
Sharma K ,
Williams J,
Kwiatkowski NP
(2025) J Med Chem , 68 , 18407 - 18422
Grant Support:
- Other private: (United States)