EMD-49893
Cryo-EM structure of DDB1dB:CRBN:mezigdomide:SALL4(392-449;G416A)
EMD-49893
Single-particle2.7 Å
Deposition: 24/03/2025Map released: 04/02/2026
Last modified: 04/02/2026
Sample Organism:
Homo sapiens
Sample: Ternary complex of DDB1dB:CRBN:mezigdomide:SALL4(392-449;G416A)
Fitted models: 9nwt
Deposition Authors: Park J, Hunkeler M, Roy Burman SS
,
Fischer ES
Sample: Ternary complex of DDB1dB:CRBN:mezigdomide:SALL4(392-449;G416A)
Fitted models: 9nwt
Deposition Authors: Park J, Hunkeler M, Roy Burman SS
,
Fischer ES
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.
Slabicki M,
Park J,
Nowak RP,
Roy Burman SS ,
Pellman J,
Zou C,
Razumkov H,
Carreiro J,
Rastogi S,
Goldstein A,
Nagiec MM,
Donovan KA,
Che J,
Hunkeler M,
Geng Q,
Hsu CL,
Lakshminarayan M,
Shu C,
Zon RL,
Kozicka Z ,
Park PMC,
Tsai JM,
Yoon H,
Jones LH ,
Sperling AS,
Gray NS ,
Fischer ES,
Ebert BL
(2025) Mol Cell , 85 , 3184 - 3201.e14
,
Pellman J,
Zou C,
Razumkov H,
Carreiro J,
Rastogi S,
Goldstein A,
Nagiec MM,
Donovan KA,
Che J,
Hunkeler M,
Geng Q,
Hsu CL,
Lakshminarayan M,
Shu C,
Zon RL,
Kozicka Z ,
Park PMC,
Tsai JM,
Yoon H,
Jones LH ,
Sperling AS,
Gray NS ,
Fischer ES,
Ebert BL
(2025) Mol Cell , 85 , 3184 - 3201.e14
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