EMD-49892
Cryo-EM structure of DDB1dB:CRBN:mezigdomide:SALL4(392-449)
EMD-49892
Single-particle2.7 Å
Deposition: 24/03/2025Map released: 04/02/2026
Last modified: 04/02/2026
Sample Organism:
Homo sapiens
Sample: Ternary complex of DDB1dB:CRBN:mezigdomide:SALL4(392-449)
Fitted models: 9nws
Deposition Authors: Park J, Hunkeler M, Roy Burman SS
,
Fishcer ES
Sample: Ternary complex of DDB1dB:CRBN:mezigdomide:SALL4(392-449)
Fitted models: 9nws
Deposition Authors: Park J, Hunkeler M, Roy Burman SS
,
Fishcer ES
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.
Slabicki M,
Park J,
Nowak RP,
Roy Burman SS ,
Pellman J,
Zou C,
Razumkov H,
Carreiro J,
Rastogi S,
Goldstein A,
Nagiec MM,
Donovan KA,
Che J,
Hunkeler M,
Geng Q,
Hsu CL,
Lakshminarayan M,
Shu C,
Zon RL,
Kozicka Z ,
Park PMC,
Tsai JM,
Yoon H,
Jones LH ,
Sperling AS,
Gray NS ,
Fischer ES,
Ebert BL
(2025) Mol Cell , 85 , 3184 - 3201.e14
,
Pellman J,
Zou C,
Razumkov H,
Carreiro J,
Rastogi S,
Goldstein A,
Nagiec MM,
Donovan KA,
Che J,
Hunkeler M,
Geng Q,
Hsu CL,
Lakshminarayan M,
Shu C,
Zon RL,
Kozicka Z ,
Park PMC,
Tsai JM,
Yoon H,
Jones LH ,
Sperling AS,
Gray NS ,
Fischer ES,
Ebert BL
(2025) Mol Cell , 85 , 3184 - 3201.e14
Grant Support: