EMD-49728

Single-particle
3.29 Å
EMD-49728
3D View Gallery
Deposition: 14/03/2025
Map released: 09/07/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49728

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9nrc summary report (pdf.gz) Map-9nrc FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab

EMD-49728

Single-particle
3.29 Å
EMD-49728
3D View Gallery
Deposition: 14/03/2025
Map released: 09/07/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: TMPRSS6 in complex with REGN7999 Fab and REGN8023 Fab
Fitted models: 9nrc

Deposition Authors: Saotome K, Franklin MC
A TMPRSS6-inhibiting mAb improves disease in a beta-thalassemia mouse model and reduces iron in healthy humans.
Lob HE, Singh N, Mohammadi K, Ivanova L, Crowell B, Kim HJ, Kravets L, Das NM, Ray Y, Kim JH, Rottey S, Labriola-Tompkins E, Hassan HE, Farrelly L, Chin HF, Preda M, Spencer Noakes L, Saotome K, Franklin M, Retter MW, Karayusuf E, Flanagan JJ, Olson W, Nannuru KC, Idone V, Burczynski ME, Harari OA, Perlee L, Van Lancker G, Murphy AJ, Economides AN, Hatsell SJ
(2025) JCI Insight , 10
PUBMED: 40548380
DOI: doi:10.1172/jci.insight.191813
ISSN: 2379-3708
Grant Support: