EMD-49564
cryoEM structure of human ACKR3 phosphorylated by GRK2 in complex with Arr2
EMD-49564
Single-particle4.1 Å
Deposition: 04/03/2025Map released: 02/04/2025
Last modified: 09/07/2025
Sample Organism:
Homo sapiens
Sample: Human ACKR3 phosphorylated by GRK5 in complex with Arrestin3
Deposition Authors: Chen Q
,
Tesmer JJG
Sample: Human ACKR3 phosphorylated by GRK5 in complex with Arrestin3
Deposition Authors: Chen Q
,
Tesmer JJG
Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor.
Chen Q ,
Schafer CT ,
Mukherjee S ,
Wang K ,
Gustavsson M ,
Fuller JR ,
Tepper K,
Lamme TD ,
Aydin Y ,
Agrawal P,
Terashi G ,
Yao XQ,
Kihara D ,
Kossiakoff AA ,
Handel TM ,
Tesmer JJG
(2025) Nature , 643 , 280 - 287
,
Schafer CT ,
Mukherjee S ,
Wang K ,
Gustavsson M ,
Fuller JR ,
Tepper K,
Lamme TD ,
Aydin Y ,
Agrawal P,
Terashi G ,
Yao XQ,
Kihara D ,
Kossiakoff AA ,
Handel TM ,
Tesmer JJG
(2025) Nature , 643 , 280 - 287
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA254402 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM117372 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI161880 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA221289 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA023168 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM137505 (United States)
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI): HL071818 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA023168 (United States)
- Walther Cancer Foundation: (United States)
- Ralph W. and Grace M. Showalter Research Trust: (United States)