Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-49537

Composite map
Single-particle
2.6 Å
EMD-49537
3D View Gallery
Deposition: 04/03/2025
Map released: 08/10/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49537
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9nmq summary report (pdf.gz) Map and 9nmq FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; closed pore)

EMD-49537

Composite map
Single-particle
2.6 Å
EMD-49537
3D View Gallery
Deposition: 04/03/2025
Map released: 08/10/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Complex of RyR1 with Calstabin-1 in presence of simvastatin (Ca2+/CFF/ATP condition)
Fitted models: 9nmq

Deposition Authors: Weninger G, Marks AR
Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation.
Weninger G, Dridi H, Reiken S, Yuan Q, Zhao N, Groom L, Leigh J, Liu Y, Tchagou C, Kang J, Chang A, Luna-Figueroa E, Miotto MC, Wronska A, Dirksen RT, Marks AR
(2025) J Clin Inv , 135
PUBMED: 41392983
DOI: doi:10.1172/JCI194490
ISSN: 0021-9738
ASTM: JCINAO