EMD-49453

Single-particle
2.89 Å
EMD-49453
3D View Gallery
Deposition: 25/02/2025
Map released: 13/05/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-49453

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ni5 summary report (pdf.gz) Map-9ni5 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the PI3K alpha/KRas/HER3 phosphopeptide complex on POPC/POPS/PIP2 nanodiscs

EMD-49453

Single-particle
2.89 Å
EMD-49453
3D View Gallery
Deposition: 25/02/2025
Map released: 13/05/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: full-length p85 alpha and p110 alpha heterodimer/KRas/HER3 phosphopeptide complex bound to POPC/POPS/PIP2-MSP1E3D1 nanodiscs
Fitted models: 9ni5

Deposition Authors: Torosyan H, Natalia J, Verba KA
Structures of the PI3K alpha /KRas complex on lipid bilayers reveal molecular mechanisms of PI3K alpha activation.
Torosyan H, Paul MD, Meyer BG, Maker A, Jura N, Verba KA
(2026) Mol Cell , 86 , 2858
PUBMED: 42349404
DOI: doi:10.1016/j.molcel.2026.06.010
ISSN: 1097-2765
ASTM: MOCEFL