EMD-49119
PROTAC-induced IRE1 ternary complex
EMD-49119
Single-particle2.6 Å
Deposition: 07/02/2025Map released: 05/11/2025
Last modified: 22/04/2026
Sample Organism:
Homo sapiens
Sample: IRE1:G6374:VHL:Eloc:Elob
Fitted models: 9n88
Deposition Authors: Du J
,
Johnson M,
Azumaya C,
Rohou A ,
Hsu PL ,
Ashkenazi A
Sample: IRE1:G6374:VHL:Eloc:Elob
Fitted models: 9n88
Deposition Authors: Du J
,
Johnson M,
Azumaya C,
Rohou A ,
Hsu PL ,
Ashkenazi A
Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.
Du J ,
Villemure E,
Johnson M,
Azumaya C,
Gaspar CJ,
Marsters S,
Lawrence D,
Foster S,
Rohou A ,
Cheung TK,
Rose CM,
Garner T,
Ro S,
Clark K,
Beresini MH,
Braun MG,
Rudolph J,
Hsu P,
Ashkenazi A
(2025) Nat Commun , 16 , 11445 - 11445
,
Villemure E,
Johnson M,
Azumaya C,
Gaspar CJ,
Marsters S,
Lawrence D,
Foster S,
Rohou A ,
Cheung TK,
Rose CM,
Garner T,
Ro S,
Clark K,
Beresini MH,
Braun MG,
Rudolph J,
Hsu P,
Ashkenazi A
(2025) Nat Commun , 16 , 11445 - 11445
Grant Support:
- Other private: (United States)